pyrazol-4-yl-pyrrolo 2,3-d pyrimidines and n- (hetero) aryl-pyrrolidine derivatives and pyrrol-3-yl-pyrrolo 2,3-d pyrimidines as janus kinase inhibitors.

摘要

compound pyrazol-4-pyrrol [2-3-d] pyrimidines and n- (hetero) aryl-pyrrolidine derivatives and pyrrol-3-yl-pyrrol [2,3-d] pyrimidines as janus kinase inhibitors, pharmaceutical compositions comprising said compound and use thereof. the present invention relates to n- (hetero) aryl-pyrrolidine derivatives of formula i: which are inhibitors of jak, such as selective inhibitors of jak1, useful in the treatment of diseases associated with jak including, for example, inflammatory disorders and autoimmune diseases, as well as cancer,