N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo 2,3-dpyrimidines and pyrrol-3-yl-pyrrolo 2,3-dpyrrimidines as janus kinase inhibitors

摘要

The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.