PIRENZEPINE AND DERIVATIVES THEREOF AS ANTI-AMYLOID AGENTS

摘要

Disclosed is the use of pirenzepine derivative represented by general formula (I), such as clozapine, for the treatment of a disease or condition, which is caused by or associated with the formation of beta-amyloid plaques in the brain, in an animal suffering from said disease or condition by (a) reducing the beta-amyloid plaque load, and/or (b) inhibiting the formation of beta-amyloid plaques and/or (c) retarding the increase of amyloid load in the brain of the treated animal, thereby retaining or increasing cognitive memory capacity in said animal. Such diseases can include Guam Parkinson-Dementia complex; diseases based on or associated with amyloid-like proteins; Creutzfeld Jacob disease, Parkinson's disease, HIV-related dementia, ALS (amyotropic lateral sclerosis), Adult Onset Diabetes; senile cardiac amyloidosis; endocrine tumors, macular degeneration, drusen-related optic neuropathy and cataract due to beta-amyloid deposition.