METHODS AND COMPOSITIONS COMPRISING ANTAGONISTS OF TYPE 1 INTERFERON-MEDIATED SIGNALLING FOR REDUCING A NEUROINFLAMMATORY RESPONSE IN THE CENTRAL NERVOUS SYSTEM FOLLOWING A STROKE

摘要

The present disclosure relates to the amelioration of symptoms associated with a neuropathological inflammatory response component of a stroke event within the central nervous system (CNS) in a subject. Pharmaceutical formulations comprising antagonists of Type 1 interferon-mediated signalling or antagonists of interferon alpha receptor 1 mediated signalling; and methods and medical protocols for reducing neuroinflammation following a stroke are disclosed.