SYNTHESIZING METHOD OF 4-O-METHYLHONOKIOL HAVING CURATIVE ABILITY TO VARIOUS DISEASES AND SKIN LIGHTNING ACTIVITY, WITH HIGH PURITY AND HIGH YIELD

摘要

PURPOSE: A synthesizing method of 4-O-methylhonokiol is provided to mass-product 4-I-methylhonokiol with higher purity and higher yield by existing method extracting from natural material.;CONSTITUTION: A synthesizing method of 4-O-methylhonokiol comprises a step of synthesizing 4-alkyl-2-bromophenol by substituting bromine at the ortho location of 4-allylphenol; a step of synthesizing potassium 3-allyl-4-methoxyphenyltrifluoroborate from 2-allyl-4-bromo-1-anisole, and a step of synthesizing 4-O-methylhonokiol through Suzuki-Miyaura coupling reaction of 4-allyl-2-bromophenol, and potassium 3-allyl-4-methoxyphenyltrifluoroborate.;COPYRIGHT KIPO 2012