Genetically-modified cell line for producing cloned miniature pigs for xenotransplantation and method for preparing the same

摘要

The present invention relates to a heterologous epitope gene targeting vector which can at the same time as the removal of the epitope with synthetic gene homologous recombination method hits a human body and human CD39 gene or the inhibition of complement genes in the heterogeneous epitopes gene masturbation. ; Epitope synthetic genes, CMAH, CMP-Neu5Ac hydroxylase, GT, alpha 1,3 galactosyl transferase kinase, homologous recombination targeting vectors, CD39, inhibit human complement gene