Antimicrobial composition comprising synthesized gallol derivatives with effects of antioxidant and inhibition of lipid peroxidation

摘要

PURPOSE: An antibacterial composition containing amphipathic gallol derivatives is provided to ensure antioxidation in a cell membrane with low irritation. CONSTITUTION: An antibacterial composition contains an amphipathic gallol derivative of 1,2,3-trihydroxy- 4-alkylbenzene(T-OH_4R) derivatives as an active ingredient. The amphipathic gallol derivative is 4-pentylgallol, 4-pentyl-1,2,3-benzenetriol(PG), 4-pentadecylgallol(PDG), or 4-eicosylgallol, 4-eicosyl-1,2,3-benzenetriol(EG). The antibacterial composition has antibacterial activity against gram-positive bacteria including Staphylococcus aureus and Staphylococcus epidermidis; gram-negative bacteria including Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis; and pathogen including Helicobacter pylori.