AMPHIPHILIC GALLOL DERIVATIVES HAVING EXCELLENT ANTIOXIDANT CHARACTERISTICS AND LOW IRRITATION IN CELL MEMBRANES BY HAVING AMPHIPHILICS WITH MAINTAINING THE BASIC STRUCTURE OF GALLOL, AND COMPOSITIONS WITH EFFECTS OF ANTIOXIDANTS AND THE INHIBITION OF LIPID PEROXIDATION

摘要

PURPOSE: An amphiphilic gallor derivative is provided to actively inhibit the oxidation of LDL which is the cause of senile arteriosclerosis by a basic structure having a gallol structure which is a strong antioxidant active side and a long hydrocarbon side chain in the same molecule, thereby preventing diseases and providing curative power.;CONSTITUTION: An amphiphilic gallol derivative is a 1,2,3-trihydroxy-4-alkylbenzene derivative including the last compound of the drawing. In the drawing, R is C_nH_(2n+1). A manufacturing method of the amphiphilic gallol derivative comprises: a step lithium ionizing 1,2,3-trimethoxybenzene; a step alkylating the 1,2,3- trimethoxybenzene; a step obtaining 1,2,3-trimethoxy-4-alkylbenzene derivative the alkylation; a step demethoxylating the 1,2,3-trimethoxy-4-alkylbenzene; and a step obtaining the amphiphilic gallol derivative by the demethoxylation.;COPYRIGHT KIPO 2012