Benzothiazepine derivatives as ryanodine receptor (RYR2) inhibitors and their use in the treatment of cardiac diseases

摘要

The present application relates to benzothiazepine S36 and its oxidized derivatives tor use in limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject having a cardiac condition or in treating or preventing a cardiac condition in a subject.