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METHOD FOR DETERMINING THE ACTIVITY OF THE LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR LPA₂

机译：测定脂多糖（LPA）受体LPA _{2 活性的方法}

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摘要

The invention relates to a method for determining, in vitro, the specific activity of the LPA₂ receptor by measuring the expression of one or more specific markers, in particular for determining, in vitro, the modulatory activity of a compound specifically with respect to the LPA₂ receptor, in particular in the context of monitoring the efficacy of a therapeutic compound specifically targeting the LPA₂ receptor. The markers are CCN1 (CYR61) and CCN2 (CTGF) and, optionally, IL6 and IL8.

机译：本发明涉及一种通过测量一种或多种特异性标志物的表达，特别是用于确定，检测，检测LPA _{2 受体的比活性的方法。体外，特别是在监控特异性针对LPA 的治疗性化合物的功效的情况下，化合物对LPA _{2 受体的调节活性Sub> 2 受体。标记是CCN1（CYR61）和CCN2（CTGF），以及可选的IL6和IL8。}} 展开▼

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公开/公告号WO2013121160A1

专利类型

公开/公告日2013-08-22

原文格式PDF

申请/专利权人 UNIVERSITE CLAUDE BERNARD LYON I;HOSPICES CIVILS DE LYON;
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申请/专利号WO2013FR50318

发明设计人 PEYRUCHAUD OLIVIER;DAVID MARION;CLEZARDIN PHILIPPE;
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申请日2013-02-15

分类号C12Q1/68;

国家 WO

入库时间 2022-08-21 16:31:20

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METHOD FOR DETERMINING THE ACTIVITY OF THE LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR LPA2

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METHOD FOR DETERMINING THE ACTIVITY OF THE LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR LPA₂