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Modified glyceraldehyde-3-phosphate dehydrogenase from corynebacterium glutamicum and uses thereof
Modified glyceraldehyde-3-phosphate dehydrogenase from corynebacterium glutamicum and uses thereof
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机译:谷氨酸棒杆菌的改性3-磷酸甘油醛脱氢酶及其用途
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摘要
The present invention relates to enzymatically active glyceraldehyde-3-phosphate dehydrogenase enzymes, which have been modified in their primary structure to alter their coenzyme specificity. In particular, the modified enzymes of the invention exhibit an improved specificity for the coenzyme NADPH which is associated with several advantages in terms of their applicability in biotechnological processes. The invention also provides methods for producing an amino acid, in particular L-lysine or L-threonine, which make use of the modified glyceraldehyde-3-phosphate dehydrogenase enzyme. The invention also relates to the use of the modified glyceraldehyde-3-phosphate dehydrogenase enzyme for biotechnological production processes.
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