ANTITUMOR BIOLOGICAL COMPLEX OF HYALURONIC ACID OR DERIVATIVE THEREOF OBTAINED BY INDIRECT CHEMICAL COMPLEX FORMATION, AND THEIR USE IN MEDICAL FIELD

摘要

PROBLEM TO BE SOLVED: To provide a new biological complex group, method for producing the same, and use in oncologic field.SOLUTION: An antitumor biological complex can be obtained by indirect synthesis means using a molecular spacer between hyaluronic acid and/or a derivative thereof and a medicine with antitumor activity belonging to various groups. The new derivative has various physical and chemical characteristics regarding a bond type and a substitution degree, the resistance and effectiveness thereof are improved by the characteristics, and the more correct regulation of a dose and an active target guidance mechanism are made available.