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Anti-tumor bioconjugates of hyaluronic acid or its derivatives obtained by indirect chemical complex formation and their use in the pharmaceutical field
Anti-tumor bioconjugates of hyaluronic acid or its derivatives obtained by indirect chemical complex formation and their use in the pharmaceutical field
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机译:通过间接化学配合物形成获得的透明质酸或其衍生物的抗肿瘤生物缀合物及其在制药领域的用途
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摘要
The present invention describes a new group of bioconjugates which can be obtained by means of indirect synthesis, via a molecular spacer, between hyaluronic acid and/or its derivatives and drugs with an antitumoral activity belonging to different groups, their preparation process and use in the oncological field. The new derivatives, in relation to the type of bond and Substitution degree, have different physico-chemical properties which improve their tolerability and efficiency and allow a more accurate modulation of the dosage, exploiting an active targeting mechanism.
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