Antitumor bioconjugates of hyaluronic acid or its derivatives obtained by indirect chemical conjugation

摘要

Pharmaceutical chemical conjugates of hyaluronic acid and / or its derivatives obtained through an indirect union between the polysaccharide and a drug with an antitumor action, through a molecular spacer that forms an ester bond with the carboxylic group of HA and / or its derivative, with the proviso that said spacer is not a hydrazide or a polypeptide, the drug is doxorubicin; said hyaluronic acid derivatives are selected from salified HA with organic and / or inorganic bases having a molecular weight of 50-730 KDa or a high molecular weight of 750-1 230 KDa and the spacer is selected from bromopropionic acid or bromobutyric acid.