A piezoresistive microcantilever biochip useful for detecting and identifying the presence of clinically important analytes in liquid or gaseous samples is disclosed. The biochip consist pairs of three paddled cantilever designs of different sensitivities in an array form and in differential readout arrangement. The cantilevers designs are named high sensitive, very high sensitive and ultra high sensitive, and have, respectively, there, five and seven identical rectangular holes. And, the piezoresistor wrapped around the holes. The microcantilever designs disclosed here can also be used in individual formation on a chip. The novel cantilever designs disclosed here have much higher design sensitivity than the currently available ones, and therefore are best suited to improve the detection sensitivity of piezoresistive microcantilever biosensors. The array arrangement of these cantilevers when used on a single chip can result in a universal and dynamic detection range biochip.
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