The novel statin intermediates , as well as pitavastatin , rosuvastatin , manufacture of cerivastatin and fluvastatin method using the same .

摘要

The present invention relates to new statin intermediates of the general formula 1, as well as providing pitavastatin, rosuvastatin, a method of making a cerivastatin and fluvastatin, using the intermediate body. (In the formula, it is n = 1,2,3, Ar is a phenyl group, C. _1. ~C. _4. Alkyl or of C. _6. ~C. _10. of phenyl group substituted with an aryl, naphthyl group, C. _1. ~C. _4. of alkyl or C. _6. ~C. _10. replaced with. aryl naphthyl group, anthracene group, or C. _1. ~C. _4. of alkyl or C. _6. ~C. _10. is an aryl in substituted anthracene group, R. _1. The C. _1. ~C. _8. of alkyl, secondary alkyl, tertiary alkyl, aryl or aralkyl.).BACKGROUND.