Pharmaceutical formulations containing 3-formylrifamycin SV and 3- (4-cinnamyl-1-piperazinyl) amino derivatives of 3-formylrifamycin S and methods for their production

摘要

The present invention relates to 3-formylrifamycin SV and 3-formylrifamycin S 3 having high activity against Gram-positive and Gram-negative microorganisms and Mycobacterium tuberculosis (including variants and rifamycin resistance) as active substances. (4-cinnamyl-1-piperazinyl) -amino derivative-containing preparation method and 3-formylrifamycin SV and 3-formylrifamycin S 3- (4-cinnamyl-1- It relates to a process for the preparation of piperazinyl) -amino derivatives. The method for preparing the pharmaceutical composition is easily feasible and does not require special equipment for its implementation. Methods for preparing this compound include high yield and purity, use of environmentally clean solvents in the preparation and isolation of materials, ie, ethanol and water, and organic solvents remaining in the final product. Is not present.