PHARMACEUTICAL FORMULATIONS CONTAINING 3-(4-CINNAMYL-1-PIPERAZINYL) AMINO DERIVATIVES OF 3-FORMYLRIFAMYCIN SV AND 3-FORMYLRIFAMYCIN S AND A PROCESS OF THEIR PREPARATION

摘要

There is disclosed compounds and pharmaceutical formulations containing 3-(4-cinnamyl-1-piperazinyl)-amino derivatives of 3-formylrifamycin SV and 3-formylrifamycin S accordingtoFormula I and a second formula and a process of their preparation. In FormulaI, R can be H or Na, andR1 is H. The compounds, as active substance, possess high activity againstGram- positive andGram-negative microorganisms, as well as against tuberculous micobacteria(including atypical and rifamycinresistant). The method for the preparation of pharmaceutical formulations isreadily feasible, and doesnot require special equipment for its implementation. The process forpreparing the compounds ischaracterized by high yield and purity, using an environmental clean solvent -ethanol and water in thepreparation and isolation of substances, and the absence of residual organicsolvents in the finalproduct.(see above formula)