N-angiotensin- (1-7) peptide (arg7) and pharmaceutical compositions for disease treatment

摘要

N-angiotensin (1-7) peptide (arg °) and pharmaceutical compositions for treating diseases. The present invention consists of the (arg0) n-angiotensin- (1-7) 5 [(arg0) n-ang- (1-7)] peptide, where n is 1 to 10 (sf0 id n01, where xaa represents a variation (1-10 amino acids 1-arg), which is produced by inserting at least one arginine amino acid into the amino-terminal position of ang- (1-7), as well as pharmaceutical compositions containing this peptide and their use for treatment or prevention of diseases or disorders that are due to or have reduced nitric oxide production, with non-imitating cardiopulmonary and hepatic disorders, vasculopathies, metabolic, neural, genitourinary tract, musculoskeletal, renal, cutaneous, alopecia or tumors . The peptide is capable of causing, for example, dilation of aortic and mesenteric vessels, reduction of mean arterial pressure, decrease in body weight gain, blockade of development of visceral adiposity, reduction of serum and hepatic cholesterol levels, normalization of intolerance to glucose and insulin resistance and anti-proliferative effect. The (arg0) -ang- (1-7) peptide may optionally be associated with a carrier system or controlled drug delivery system.