Hemietanolat fisetin-nicotinamide co-crystal and a method for preparing fisetin-nicotinamide co-crystal

摘要

the invention relates to kokrysztalu hemietanolatu fizetyna - nicotinamide model 3, which applies in a pharmaceutical and / or cosmetics.the invention discloses also a way receive kokrysztalu hemietanolatu fizetyna - nicotinamide of the formula 3, charakteryzujacy thatwith fizetyne in amounts of from 25 to 50 mg and nicotinamide in amounts of from 150 to 300 mg is mixed with 5 to 10 ml of ethanol, after which together stirs, przesacza,and then leaves for slow evaporation at room temperature, and after 14 to 18 days, they harvest krysztaly.in another variation of receiving kokrysztalu hemietanolatu fizetyna - nicotinamide of the formula 3, have to fizetyne and nicotinamide in 1: 2 of the stoichiometric in steel vessel mlyna ball,what's in the ethanol of 50? l for every 50 mg fizetyny, then mieszanine being milled by time from 5 to 45 minutes, with czestosci drgan 50 - 60 hzand so obtained microcrystalline material drought in room temperature by time from 12 to 24 hours and subjected to analysis on dyfraktometrze proszkowym.