ANTI-CLASS 5 FIMBRIAL ADHESIN-BASED PASSIVE IMMUNOPROPHYLACTIC

摘要

The invention relates to a method of producing a pharmaceutical compositionthatincludes anti-class 5 Escherichia coli immunoglobulin from domesticatedanimals, and whichis useful as a passive immunoprophylactic against class 5 enterotoxigenicEscherichia coli.The immunogen used to induce anti-class 5 E. coli immunity in the domesticatedanimalsincludes one or more constructs including stabilized enterotoxigenicEscherichia coli fimbrialadhesin or an adhesin domain of CfaE, CsbD or CotD. The immunoprophylactic ismade bycollecting anti-adhesin immunoglobulin in the colostrum or milk of vaccinateddomesticatedanimals, such as cows.