首页> 外国专利> DIAGNOSTIC METHOD FOR DETECTING ACUTE KIDNEY INJURY USING HEAT SHOCK PROTEIN 72 AS A SENSITIVE BIOMARKER

DIAGNOSTIC METHOD FOR DETECTING ACUTE KIDNEY INJURY USING HEAT SHOCK PROTEIN 72 AS A SENSITIVE BIOMARKER

机译:以热休克蛋白72为敏感生物标志物的诊断急性肾脏损伤的诊断方法。

摘要

The invention relates to a reliable, easy-to-implement non-invasive diagnostic method for detecting early acute kidney injury by measuring the concentration of a biomarker in urine samples, said biomarker being selected from heat shock proteins of the 70 KDa family. More specifically, the invention relates to the identification of heat shock protein 72, whereby said biomarker is identified by means of ELISA and Western blot or by means of the level of RNAm using real-time RT-PCR. The invention helps to solve the current problem that exists in medicine whereby it is not possible to detect acute renal failure in the early stages or the severity of the renal damage in order to treat the patient in a timely manner with an effective therapy.
机译:本发明涉及通过测量尿液样品中生物标志物的浓度来检测早期急性肾损伤的可靠,易于实施的非侵入性诊断方法,所述生物标志物选自70KDa家族的热激蛋白。更具体地,本发明涉及热激蛋白72的鉴定,其中所述生物标志物通过ELISA和Western印迹或使用实时RT-PCR通过RNAm的水平来鉴定。本发明有助于解决医学中存在的当前问题,即不可能在早期发现急性肾功能衰竭或肾脏损害的严重性以便及时用有效疗法治疗患者。

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