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SUBSTITUTED CARBAMATE COMPOUNDS AND THEIR USE AS TRANSIENT RECEPTOR POTENTIAL(TRP) CHANNEL ANTAGONISTS

机译:取代的氨基甲酸酯化合物及其作为瞬态受体电位(TRP)通道拮抗剂的用途

摘要

The present invention relates to compounds of the formula (I): EMI ID = 4.1 and pharmaceutically acceptable salts thereof, Wherein Y, R 1 and R 3 are as defined herein. The present invention also relates to pharmaceutical compositions comprising such compounds, as well as methods of making and using the compounds of formula (I). The compounds of formula (I) are antagonists of the TRPA1 channel and may be useful in treating diseases and disorders associated with the channel.
机译:本发明涉及式(I)的化合物及其药学上可接受的盐,其中Y,R 1和R 3如本文所定义。本发明还涉及包含此类化合物的药物组合物,以及制备和使用式(I)化合物的方法。式(I)化合物是TRPA1通道的拮抗剂,可用于治疗与该通道有关的疾病和病症。

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