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SUBSTITUTED CARBAMATE COMPOUNDS AND THEIR USE AS TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNEL ANTAGONISTS

机译:取代的氨基甲酸酯化合物及其作为瞬态受体电位(TRP)通道拮抗剂的用途

摘要

The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein Y, R1 and R3 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists of the TRPA1 channel and may be useful in treating inflammatory diseases and disorders associated with that channel.
机译:本发明涉及式(I)的化合物:及其药学上可接受的盐,其中Y,R 1和R 3在详细描述和权利要求中定义。另外,本发明涉及制造和使用式(I)的化合物的方法以及包含此类化合物的药物组合物。式(I)的化合物是TRPA1通道的拮抗剂,可用于治疗与该通道有关的炎性疾病和病症。

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