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CONJUGATE OF GINSENOSIDE COMPOUND K AND GLYCOL CHITOSAN AND AN ANTI-TUMOR USE THEREOF

机译:人参皂甙复合物K和乙二醇壳聚糖的结合及其抗肿瘤用途

摘要

The present invention relates to a conjugate of ginsenoside compound K and glycol chitosan, a method for preparing the conjugate, and a pharmaceutical composition for treating cancer including the conjugate in a pharmaceutically acceptable carrier.;The conjugate of ginsenoside compound K and glycol chitosan of the present invention has cancer cell-specific anticancer activity because of increased water solubility relative to ginsenoside compound K, formation of nanosized self-aggregates in an aqueous solution, stability at neutral pH and release of the ginsenoside compound K at acidic pH due to pH sensitivity, thus having excellent effects as a composition for treating cancer.
机译:本发明涉及人参皂苷化合物K与乙二醇壳聚糖的缀合物,其制备方法以及用于治疗癌症的药物组合物,所述药物组合物包括人参皂苷化合物K与乙二醇壳聚糖的缀合物。本发明具有癌细胞特异性的抗癌活性,这是由于相对于人参皂苷化合物K的水溶性增加,在水溶液中形成纳米尺寸的自聚集体,在中性pH下的稳定性以及由于pH敏感性在酸性pH下人参皂苷化合物K的释放,因此作为治疗癌症的组合物具有优异的效果。

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