Preparation and characterization of poly(propylene glycol)-conjugated cationic polymers for efficient gene delivery

摘要

Nucleic acid drugs are desirable therapeutics for the treatment of fatal diseases like cancers.For clinical translation of nucleic acid drugs,carrier systems that protect nucleic acid from degradation and help cellular uptake are needed.Accordingly cationic polymers are used as a carrier due to their strong electrostatic interaction with nucleic acids,which produce nanosized particles[1].