An anti-human-norovirus GII antibody which responds to substantially all genotypes of the human noroviruses belonging to GII and which can comprehensively detect such human noroviruses GII. The anti-human-norovirus GII antibody that binds to at least one of epitopes which are contained in amino acid regions represented by the following formulas (1) and (2):P-X1-X2-P-G-E (1) (SEQ ID NO: 2)X3-X4-X5-F-Y-X6-L-X7-P-X8 (2) (SEQ ID NO: 3)(wherein, X1 represents L, V, N, T, S, M, or R; X2 represents F, Y, or M; X3 represents V or G; X4 represents N or S; X5 represents Q, P, or S; X6 represents S, T, or I; X7 represents A or S; and X8 represents M or V), and of an epitope formed of amino acid 483 of the amino acid sequence represented by SEQ ID NO: 1, or an epitope formed of an amino acid corresponding to amino acid 483, the regions and the amino acids being present in the P domain of a capsid structural protein of a human norovirus GII.
展开▼
机译：一种抗人诺如病毒GII抗体，该抗体可对属于GII的人诺如病毒的几乎所有基因型作出反应，并可全面检测此类人诺如病毒GII。抗人诺如病毒GII抗体与以下式（1）和（2）表示的氨基酸区域中包含的至少一个表位结合：<？in-line-formulae description =“在线公式” end =“ lead”？> PX 1 -X 2 -PGE（1）（SEQ ID NO ：2）<？in-line-formulae description =“ In-line Formulae” end =“ tail”？> <？in-line-formulae description =“ In-line Formulae” end =“ lead”？> X 3 -X 4 -X 5 -FYX 6 -LX 7 -PX 8 （2）（SEQ ID NO：3）<？in-line-formulae description =“在线表达式” end =“ tail”？>（其中X 1 代表L，V，N，T，S，M或R; X 2 代表F，Y或M; X 3 表示V或G; X 4 表示N或S; X 5 表示Q，P或S; X 6 表示S，T或I; X 7 代表A或S; X 8 代表M或V）以及由氨基酸483位氨基酸组成的表位由SEQ ID NO：1表示的序列或由对应于氨基酸483的氨基酸形成的表位，所述区域和氨基酸存在于人诺如病毒GII的衣壳结构蛋白的P结构域中。
展开▼
