Provided is an anti-human-norovirus GII antibody which responds to substantially all genotypes of the human noroviruses belonging to GII and which can comprehensively detect such human noroviruses GII. The anti-human-norovirus GII antibody that binds to at least one of epitopes which are contained in amino acid regions represented by the following formulas (1) and (2): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒP-X 1 -X 2 -P-G-E€ƒ€ƒ€ƒ€ƒ€ƒ(1) €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒX 3 -X 4 -X 5 -F-Y-X 6 -L-X 7 -P-X 8 €ƒ€ƒ€ƒ€ƒ€ƒ(2) (wherein, X 1 represents L, V, N, T, S, M, or R; X 2 represents F, Y, or M; X 3 represents V or G; X 4 represents N or S; X 5 represents Q, P, or S; X 6 represents S, T, or I; X 7 represents A or S; and X 8 represents M or V), and of an epitope formed of amino acid 483 of the amino acid sequence represented by SEQ ID NO: 1, or an epitope formed of an amino acid corresponding to amino acid 483, the regions and the amino acids being present in the P domain of a capsid structural protein of a human norovirus GII.
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机译:提供了抗人诺如病毒GII抗体,其对属于GII的人诺如病毒的几乎所有基因型均具有反应,并且可以全面检测此类人诺如病毒GII。抗人诺如病毒GII抗体与以下式(1)和(2)表示的氨基酸区域中包含的至少一个表位结合:€-P-X 1 -X 2 -P-G-E€(1)€3 -X 4 -X 5 -F-Y-X 6 -L-X 7 -P-X 8€(2)(其中,X 1代表L,V,N,T,S,M或R; X 2代表F,Y或M; X 3代表V或G; X 4代表N或S; X 5代表Q, P,或S; X 6代表S,T或I; X 7代表A或S; X 8代表M或V),以及由SEQ ID NO表示的氨基酸序列的483位氨基酸形成的表位1:或由对应于氨基酸483的氨基酸形成的表位,该区域和氨基酸存在于人诺如病毒GII的衣壳结构蛋白的P结构域中。
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