2,3-DESIGNED DERIVATIVES OF 1-ACYL-4-AMINO-1,2,3,4-TETRAHYDROCHINOLINES AND THEIR APPLICATION AS A BROMODOMENE INHIBITORS

摘要

The present invention relates to new compounds of formula (I), where R 7 is C1-6 alkyl; R4 is C1-6 alkyl, Ccycloalkyl, -CHCF, -CHOCH2 or heterocyclyl; R4 is C1-6 alkyl, -CHF, -CHOH or -CHO (O) CH; R, when present, is as defined in claim 1; R, when present, is H, halogen, hydroxy or C 1-6 alkoxy; A is -NH-, -O-, -S-, -SO-, -SO-, -N (C1-6 alkyl) - or -NC (O) (CH) -; V is phenyl, a heteroaromatic ring or pyridone, each of which may optionally be substituted with 1, 2 or 3 substituents; W is CH or N; X is C or N; Y is C or N; and Z is CH or N; with the proviso that no more than 2 of W, X, Y, and Z are N; to pharmaceutical compositions containing such compounds, and to their use as inhibitors of bromo domains.