USE OF 4'-THIO-2'-DEOXYNUCLEOSIDES AS ANTI ORTHOPOXVIRUS AGENTS

摘要

Compound represented by the formulae: wherein each R individually is H oraliphatic acyl or aromatic acyl group;X is selected from the group consisting of hydrogen, fluoro, chloro, bromo,iodo, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl,alkynyl, amino, monoalkylamino, dialkylamino, cyano, aryl and nitro;pharmaceutically acceptable salts thereof, prodrugs thereofand mixtures thereof are used as inhibitors of orthopoxviruses and fortreating patients suffering from an orthopoxvirus infectionsuch as, but not limited to, smallpox, cowpox, monkeypox and camelpox.