ADP- -1 -1 2H- SUBSTITUTED PHTHALAZIN-1 2H-ONE DERIVATIVES AS SELECTIVE INHIBITORS OF POLY ADP-RIBOSE POLYMERASE-1

摘要

The present invention relates to novel compounds of general formula (I), their stereoisomers, their regioisomers, their tautomeric forms and the novel intermediates associated therewith, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and And a pharmaceutical composition containing the same. The present invention also relates to a novel compound of general formula (I), a stereoisomer thereof, a regioisomer thereof, a tautomeric form thereof, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable solvate thereof and a pharmaceutical composition containing the same, And to a process for the preparation of the novel intermediates relating to the synthesis thereof. Such compounds of formula (I) are useful as PARP-1 inhibitors, for example, for the treatment of cancer.