Poly (ADP-ribose) polymerase-1 gene polymorphism in various Chinese nationalities

摘要

Poly(ADP-ribose) polymerase-1(PARP-1) can exacerbate ischemic brain injury and lessen ischemic neuronal death,which may be associated with PARP-1 polymorphisms.The present study investigated human PARP-1 gene polymorphisms in various Chinese nationalities,the results of which could potentially help in the treatment and prevention of neurologic diseases.Genetic polymorphisms of seven exons in the PARP-1 gene,in 898 Chinese Han,Buyi,Shui,Miao,and Zhuang subjects,were investigated by PCR-single-strand conformation polymorphism.A single-strand conformation polymorphism variant in exons 12,13,16,and 17 of the PARP-1 gene was identified in 148 people,with two stationary bands showing three degenerative single strands.Results showed that the PARP-1 gene polymorphisms exist in various nationalities,and may act as a biomarker for susceptibility to disease.