showing antiviral activity on A/H1N1 influenza virus. The presented agent (GA amide (1)) is 5 times less toxic for MDCK cells (CTD50 300 mcg/ml) than rimantadin, a known antiviral preparation (CTD50 60 mcg/ml), and possesses high antiviral activity; 50% effective concentration (EC50) of GA amide (1) is 0.2 mcg/ml, and in reference preparations: GA - 174 mcg/ml, rimantadin - 12 mcg/ml. GA amide (1) has a higher selectivity index (SI 1500) as compared to the reference preparations and 500 times as high as that of GA (SI 3.0) and 300 times as much as that of rimantadin (SI 5.0).;EFFECT: higher selectivity index of amide.;1 tbl, 3 ex"/>
AGENT REPRESENTING GLYCYRRHIZIC ACID AMIDE WITH 5-AMINOURACIL SHOWING ANTIVIRAL ACTIVITY ON A/H1N1 INFLUENZA VIRUS
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AGENT REPRESENTING GLYCYRRHIZIC ACID AMIDE WITH 5-AMINOURACIL SHOWING ANTIVIRAL ACTIVITY ON A/H1N1 INFLUENZA VIRUS
AGENT REPRESENTING GLYCYRRHIZIC ACID AMIDE WITH 5-AMINOURACIL SHOWING ANTIVIRAL ACTIVITY ON A/H1N1 INFLUENZA VIRUS
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机译：具有5种氨基嘧啶的甘草酸酰胺类药物在A / H1N1流感病毒中的抗病毒活性
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摘要
FIELD: medicine.;SUBSTANCE: invention refers to an agent representing glycyrrhizic acid amide with 5-aminouracil of formula (1) showing antiviral activity on A/H1N1 influenza virus. The presented agent (GA amide (1)) is 5 times less toxic for MDCK cells (CTD50 300 mcg/ml) than rimantadin, a known antiviral preparation (CTD50 60 mcg/ml), and possesses high antiviral activity; 50% effective concentration (EC50) of GA amide (1) is 0.2 mcg/ml, and in reference preparations: GA - 174 mcg/ml, rimantadin - 12 mcg/ml. GA amide (1) has a higher selectivity index (SI 1500) as compared to the reference preparations and 500 times as high as that of GA (SI 3.0) and 300 times as much as that of rimantadin (SI 5.0).;EFFECT: higher selectivity index of amide.;1 tbl, 3 ex
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机译：技术领域本发明涉及代表具有式（1）的5-氨基尿嘧啶的甘草酸酰胺的试剂。显示对A / H1N1流感病毒具有抗病毒活性。所介绍的试剂（GA酰胺（1））对MDCK细胞（CTD 50 300 mcg / ml）的毒性比已知的抗病毒制剂rimantadin低5倍。 60 mcg / ml），并具有很高的抗病毒活性; GA酰胺（1）的50％有效浓度（EC 50 ）为0.2 mcg / ml，在参考制剂中：GA-174 mcg / ml，rimantadin-12 mcg / ml。 GA酰胺（1）与参考制剂相比具有更高的选择性指数（SI 1500），是GA（SI 3.0）的500倍，是金刚烷胺（SI 5.0）的300倍。较高的酰胺选择性指数。; 1 tbl，3 ex
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