Broad-Spectrum Antiviral Activity of Nucleic Acid-Based Antiviral Agents Against Avian and Seasonal Influenza Viruses

摘要

The increasing prevalence of influenza viruses resistant to antiviral drugs such as amantadine and oseltamivir undermines our ability to defend against future influenza pandemics. There is an urgent need to develop novel antiviral agents which are robust and offer broad-spectrum protection against the ever changing influenza viruses. The objective of this study is to evaluate the in vivo antiviral efficacy nucleic acid-based immunomodulators such as Poly ICLC (synthetic ds RNA) and oligonucleotides containing unmethylated CpG using a mouse lethal infection model with influenza A/PR/8/34 (H1N1) and/or with the highly pathogenic avian influenza H5N1 (HPAI) viruses.