MULTI-SUBSTITUTED HYDROXYAPATITES AND COMPOSITION THEREOF WITH A NATURAL AND / OR SYNTHETIC POLYMER, PREPARATION AND APPLICATIONS THEREOF

摘要

The present invention relates to a hydroxyapatite multi-substituted with, physiologically compatible ion species and to its biohybrid composite with a natural and/or synthetic polymer, which are useful in the preparation of a biomimetic bone substitute for treating bone tissue defects. Furthermore, the present invention relates to a method for their preparation and uses.