Síntesis y Caracterización de Hidroxiapatita Sintética para la Preparación de Filmes de PLGA/HAp con Potencial Uso en Aplicaciones Biomédicas - Synthesis and Characterization of Synthetic Hydroxyapatite for the Preparation of PLGA/HAp Films with a Potential Use in Biomedical Applications

摘要

Fracture fixation implants are used to resolve a bone fracture, currently; there are a variety of devices such as intramedullary needles, tacks and, metal screws. Its function is to stabilize bone fragments in their correct place during their bone repair, to achieve an early vascularization. The objective of this study is to synthesize and physiochemically characterize of synthetic hydroxyapatite for the manufacturing of PLGA 50: 50 / Hap films. Through the Fourier transform infrared spectroscopy technique (FTIR) to look for main functional groups. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) to evaluate the behavior of films with respect to temperature and characterize the surface with scanning electron microscopy (SEM). The FTIR spectrum shows signs of great interest: the aromatic zone is observed between 1600 cm-1-1400 cm-1, characteristic signal of the aromatic aldehydes (C = O) at 1700 cm-1, aromatic alkenes (C = O) at 1300 cm-1 with overlapping signals -CH, = CH, additional a fourth signal very wide between 3400-2400cm-1 assigned to -OH. SEM micrographs show homogeneity on the surface. The TGA thermogram, a material loss is observed at 180 ° C of approximately 5% and another at 252 °C of 10%. Finally, the DSC thermogram is observed around 50 to 70 °C, a slight and wide change allows us to believe that this is the glass transition zone of the material, and a peak was found around 52.07 °C, where proposes that the degradation of the formulation occurs. As future work, biocompatibility and degradation tests will be carried out.