METHODS FOR TREATING A PATIENT WITH VEGFR INHIBITOR-RESISTANT METASTATIC RENAL CELL CARCINOMA

摘要

The invention relates to methods for treating a patient with VEGFR inhibitor-resistant metastatic renal cell carcinoma (mRCC). More particularly, the invention relates to a drug or a combination of drugs selected from the group consisting of a proteasome inhibitor, an efflux inhibitor or a combination of an efflux inhibitor and a lysosomotropic agent for use in a method for treating mRCC in a patient with an acquired resistance to treatment with a multi-targeted weak base VEGFR tyrosine kinase inhibitor (TKI).