The Effect of Different Surgical Methods on the Number of Circulating Tumor Cells in the Peripheral Blood of Patients with Renal Cell Carcinoma

摘要

Objective: style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> T style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">he style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">objective style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">is to style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">explore the effects of different surgical methods-retroperitoneal style="font-family:""> style="font-family:Verdana;"> laparoscopic radical nephrectomy (RLRN) and open radical style="font-family:Verdana;">nephrectomy (ORN) on the number of circulating tumor cells (CTC) in the peripheral blood of patients with renal cancer. style="font-family:Verdana;">Methods: style="font-family:Verdana;"> The clinical data of style="font-family:Verdana;"> 63 patients in the Department of Urology, Affiliated Hospital of Chengde Medical College who underwent radical surgery for renal cancer were divided into CTC positive group (18 cases of open surgery and 16 cases of minimally invasive surgery) and CTC negative group (14 cases of open surgery), 15 cases of minimally invasive surgery), overall group (32 cases of open surgery, 31 cases of minimally invasive surgery). Observe the changes in the number of CTC 1 week before operation and 1 week after operation. style="font-family:Verdana;">Results: style="font-family:Verdana;"> In the positive group, whether it was open surgery or minimally invasive surgery, the postoperative CTC level of patients was significantly reduced (P < 0.05). In the negative group, the CTC decreased significantly after open surgery (P > 0.05), and the CTC level decreased significantly after minimally invasive surgery (P < 0.01). In the overall group, both open and minimally invasive surgery CTC decreased significantly, and the difference was statistically significant (P < 0.05). style="font-family:Verdana;">Conclusion: style="font-family:Verdana;"> The two different surgical methods can reduce the level of CTC, but compared with ORN, RLRN can significantly reduce the number of postoperative CTC. Patients in the CTC-negative group may be less suitable for open surgery. CTC levels have certain potential in the selection and guidance of treatment modes for patients with renal cell carcinoma (RCC).