首页> 外国专利> KCNQ NOVEL KCNQ POTASSIUM CHANNEL AGONIST AND PREPARATION METHOD THEREFOR AND USE THEREOF

KCNQ NOVEL KCNQ POTASSIUM CHANNEL AGONIST AND PREPARATION METHOD THEREFOR AND USE THEREOF

机译:KCNQ新型KCNQ钾离子通道激动剂及其制备方法和用途

摘要

The present invention also relates to a compound having the structure of the general formula: or a pharmaceutically acceptable salt thereof, a process for preparing the same, and a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt thereof as a neurogenic disease such as epilepsy, Ischemic stroke, and neurodegenerative diseases. The compound according to the present invention has a better brain tissue absorption effect as compared with retigabine. In addition, the compound of the present invention significantly increases the drug effect, and the neurotoxic side effect remarkably falls as compared with retigabine, and thus has a wider safety window.
机译:本发明还涉及具有通式结构的化合物或其药学上可接受的盐,其制备方法,以及包含所述化合物或其药学上可接受的盐的药物组合物,其作为神经源性疾病例如癫痫病,缺血性中风和神经退行性疾病。与瑞替加滨相比,本发明的化合物具有更好的脑组织吸收作用。另外,本发明的化合物与瑞替加滨相比显着提高了药物作用,并且神经毒性副作用显着降低,因此具有更宽的安全窗。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号