Provided are a system and a method for three dimensional (3D) vision inspection using a 3D vision system. The system and the method comprises: acquiring at least one 3D image of a 3D object using the 3D vision system; using the 3D vision system to extract a 3D visible runtime mask of the 3D image; using the 3D vision system to compare the 3D runtime visible mask to a 3D reference visible mask; and using the 3D vision system to determine if a difference of pixels exists between the 3D runtime visible mask and the 3D reference visible mask.
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