FIELD: chemistry.;SUBSTANCE: invention relates to a method for synthesis of 3,6-bis-[N-protected aminoalkyl]-2,5-diketopiperazine. Method involves heating a mixture of amino acids of general formula I in presence of catalyst in an organic solvent. Said catalyst is phosphorus pentoxide, which is present in concentration of 20 mol% to 50 mol% with respect to concentration of amino acids; n equals 2 or 3; PG represents trifluoroacetyl, and said solvent is selected from a group consisting of dimethylacetamide, N-methyl-2-pyrrolidone, diglyme, ethyl glyme, proglyme and ethyldiglyme. Invention also relates to a method for synthesis of 3,6-bis-4-(N-trifluoroacetyl)aminobutyl-2,5-diketopiperazine, which involves heating a mixture of ε-trifluoroacetyl-L-lysine in presence of phosphorus pentoxide in N-methyl-2-pyrrolidone to temperature from 150 to 175 °C for 0.25–5 h, wherein concentration of phosphorus pentoxide ranges from approximately 20 mol% to approximately 35 mol% of concentration of ε-trifluoroacetyl-L-lysine, and slaking said mixture with a second solvent.;EFFECT: disclosed methods ensure high output of reaction.;8 cl, 4 tbl, 3 dwg, 10 ex
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