ANTIGENS ASSOCIATED WITH INFLAMMATORY BOWEL DISEASE

摘要

FIELD: biochemistry.;SUBSTANCE: invention relates to biochemistry. Application of antibody or its antigen-binding fragment is described binding extra domain A (ED-A) of fibronectin, conjugated with immunosuppressive or anti-inflammatory molecule, wherein above antibody includes VH domain (variable heavy chain domain) and VL domain (variable light chain domain), where VH domain contains amino acid sequences CDR1 (determining complementarity area 1), CDR2 and CDR3 of heavy chain in SEQ ID NO: 7 and VL domain contains amino acid sequences CDR1, CDR2 and CDR3 of light chain in SEQ ID NO: 8 for treating inflammatory bowel disease (IBD).;EFFECT: invention extends range of products for treating inflammatory bowel disease (IBD).;25 cl, 7 dwg