Combination dosage form of a mu opioid receptor antagonist and an opioid agent

摘要

The invention provides a solid composition of the peripheral mu opioid antagonist axelopran and a combination dosage form of the opioid mu antagonist axelopran sulfate in an immediate release form and an opioid analgesic agent which may be in prolonged release, continuous release. , modified release or controlled release form and methods of preparing such a combination dosage form.