The present disclosure discusses a system and method that includes a microfluidic device that can be used in either an extracorporeal or implantable configuration. The device supports efficient and safe removal of carbon dioxide from the blood of patients suffering from respiratory disease or injury. The microfluidic device can be a multilayer device that includes gas channels and fluid channels. Distensible membranes within the device can affect a cross-sectional area of the blood channels.
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