METHOD FOR PRODUCING FIBROSIS DISEASE MODEL, AND USE OF FIBROSIS DISEASE MODEL

摘要

The present invention provides a method for producing a fibrotic disease model, the method comprising a step of differentiating a fibrosis cell-derived induced pluripotent stem cell (iPSC) into a mesenchymal stem cell (MSC) and a step of culturing the mesenchymal stem cell with spheroids. The method for producing the fibrosis disease model is excellent in terms of time and space as compared with conventional 2D production methods in which the accumulation and decomposition processes of fibrosis-related collagen had a limit to be found, and can provide a fibrosis disease-specific model capable of more precisely reproducing the same. In addition, the model produced from the above production method can be useful for the screening of agents for inhibiting collagen accumulation and for preventing or treating fibrotic diseases.