A method for preparing of fibrosis disease models and use of fibrosis disease model

摘要

The present invention relates to a method of producing a fibrotic disease model, which comprises the steps of differentiating fibrocytoma-derived induced pluripotent stem cells (iPSC) into mesenchymal stem cells (MSC) and culturing mesenchymal stem cells with spheroids . The method of manufacturing the fibrosis disease model is superior to the conventional 2D manufacturing method in which the accumulation and decomposition processes of fibrosis-related collagen are limited, and it is superior in terms of time and space, and can be more accurately reproduced. Can be provided. In addition, the model prepared from the above production method can be used for screening of agents for inhibiting collagen accumulation and for preventing or treating fibrotic diseases.