Electrospun fibrillar biomaterial platforms with tunable mechanics as fibrosis disease models

摘要

These studies suggest that nanofiber mechanics within fibrous materials regulate cell-cell interactions and long-range force transmission via fiber displacement and alignment. This suggests that the mechanics of fibrous ECMs may shape tissue level organization found in diseases, such as bridging fibrosis in the liver. Understanding how ECM mechanics dictate scarring and cell migration could help influence the development of novel therapies. Ongoing work involves understanding the cellular mechanisms behind directed migration and nanofiber alignment.