immunogenic composition for paracoccidioidomycosis using pb40r and pb27r proteins

摘要

immunogenic composition for paracoccidioidomycosis using the proteins pb4or and pb27r. The present invention describes the development of a therapeutic vaccine that can be used as an adjuvant in the chemotherapeutic treatment of paracoccidioidomycosis (pcm). This vaccine reduces the treatment time and the risk of relapse, thus improving the prognosis of patients. This therapeutic vaccine, developed through the combined use of pb4or and pb27r proteins, led to a significant reduction in tissue damage to the lung, spleen and liver of infected mice, reaching undetectable levels of colony-forming units per g of tissue (cfu / g). .