首页> 外国专利> Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-4,5'-bipyrimidin-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof, methods of producing same, compositions comprising same and uses thereof

Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-4,5'-bipyrimidin-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof, methods of producing same, compositions comprising same and uses thereof

机译:(s)-正甲基8-(1-(((2'-甲基-[4,5'-联嘧啶] -6-基)氨基)丙-2-基)喹啉-4-羧酰胺的共晶体及其氘代衍生物,其制备方法,包含其的组合物及其用途

摘要

The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R 1 and R 2 is H or 2 H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
机译:本发明涉及各自包含具有以下结构的式I化合物的组合物和共晶体:其中R 1和R 2各自为H或2 H,并且是选自己二酸,柠檬酸,富马酸,马来酸,琥珀酸或苯甲酸的共晶形成剂。制备和使用本发明的方法也在本发明的范围内。

著录项

  • 公开/公告号IL245117A

    专利类型

  • 公开/公告日2019-10-31

    原文格式PDF

  • 申请/专利权人 VERTEX PHARMACEUTICALS INCORPORATED;

    申请/专利号IL20160245117

  • 发明设计人

    申请日2016-04-14

  • 分类号A61K31/506;A61P35;

  • 国家 IL

  • 入库时间 2022-08-21 12:02:13

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