Method for obtaining phosphatidylcholine containing ibuprofen in position sn-2 and the rest of fatty acid in position sn-1

摘要

the object of the application is a way to receive 1 acyl - 2 - [2 '- (4' - izobutylofenylo)] propanoilo - sn - glicero - 3 - fosfocholiny model 2where 1 - alkyl - 2 - lisa - sn - glicero - 3 - fosfocholinę (model 1) is subjected to the esterification of ibuprofen in anhydrous chloroform or methylene chloride, in the presence of 4 - (n, n - dimethylamino) pyridine with n,n '- dicykloheksylokarbodiimidu as coupling reagent, and reaction is carried out by at least 48 hours, after which the product is secreted by column chromatography.